At the time of their marriage Flora gave up control of many stocks and bonds to her mother so that she and Ezra would earn all their money together.
After that the Bensons returned to Ezra's home town of Whitney, Idaho where they ran a farm.
While her husband was Secretary of Agriculture, Flora on one occasion declined an invitation to the White House so that she could attend a choir performance by one of her daughters.
Benson served with her husband in Europe during the 1960s, when he was president of the European Mission, based out of Frankfurt, Germany.
In the LDS Church, she also served in a ward Relief Society presidency, as what would now be called ward Young Women president, as a member of a stake Young Women board, and as a teacher in both the Primary and Sunday School organizations.