She wrote two romance novels based in the Middle East; The God of Things (1902) and The Effendi (1904), which were both published by Little, Brown and Company.

In 1915 she helped launch the Maine branch of the National Woman's Party (NWP), and was asked to serve as its chairman, a role she played for at least the next 13 years.

In 1918-19, she led the effort in Maine to put pressure on United States Senator Frederick Hale to vote in favor of the federal amendment that would enfranchise women.

Hale was on the short list of Senators who might be persuaded to support the amendment, and Florence organized letter-writing campaigns, delegations, speeches and a variety of other efforts to get him to change his mind.

She also dedicated herself to working for world peace; she joined the National Council on Prevention of War, chaired the Government and International Cooperation Committee of the Maine League of Women Voters, served as the state Chairman of Government and international cooperation for the Maine Federation of Churches, and represented the State Peace Commission on the World Unity Council.