SR 429 traverses some of the highest elevations in Orange County and is often within a few miles of the Lake Wales Ridge.

The road peaks at Mile Marker 13 where on clear days it is possible to see the skyline of downtown Orlando to the northeast and various portions of Walt Disney World Resort to the southeast.

The road itself was finished in July 2000, temporarily ending at SR 50, and the four-level cloverstack interchange with Florida's Turnpike was completed in February 2001.

Thus, this rerouting shifted the roadway to the west, allowing it to continue north of US-441 on secured land before turning eastward and rejoining the right-of-way that was planned for construction of the long-awaited Wekiva Parkway.

It had been under debate for over a decade due to its planned alignment being complicated by the ecologically fragile Wekiva River basin, shifting support from Lake County, and the need to re-align the planned path due to the original route being blocked by residential development to the north of Section A’s northern terminal junction with US-441.

On May 25, 2011, the Florida Department of Transportation and CFX announced that they were partnering to jointly explore the construction of the Wekiva Parkway extension.

The proposed route will extend through Orange, Lake, and Seminole Counties and is estimated to cost $1.8 billion.

[6] On March 31, 2018, the Wekiva Parkway's mainline was extended from Kelly Park Road to a new northern terminus at SR 46.

The final 12-mile (19 km) section of the Wekiva Parkway between SR 46 and I-4 is under construction and is planned to open in 2023.

[11] On August 1, 2022, the northbound lanes of a 2-mile (3.2 km) section of the Wekiva Parkway between SR 46 just west of Longwood Markham Road and SR 46 just west of Orange Boulevard in Seminole County opened to traffic,[12] while the southbound lanes opened to traffic on August 15, 2022.

An extended cold snap required the contractor to push to reach the opening date, although the interchanges at Western Way and Seidel Road were not complete.