Originally the main thouroughfare connecting the major cities of Central Florida, this has since been superseded by Interstate 4, which runs nearly the same route.

After crossing the Gandy Bridge, US 92 intersects West Shore Boulevard and runs east along Gandy Boulevard until it reaches Dale Mabry Highway at the first interchange with the Lee Roy Selmon Expressway where it turns north.

In downtown Plant City, US 92 encounters SR 39A which it has a two-block overlap between Wheeler and Collins Streets.

East of SR 533, the road encounters a random series of level crossings for freight spurs leading from the CSX Lakeland Subdivision.

It also passes by a former truck weigh station, and then runs beneath Florida State Road 570 (Polk Parkway) with no direct access.

After the intersection with Florida State Road 572, it passes by the Silver Moon Drive-In in the former unincorporated community of Winston.

Entering the city of Lakeland, Florida, US 92 approaches the intersection with Wabash Avenue (hidden Florida State Road 517) and makes a brief turn to the north, while SR 600 continues eastbound unmarked along George Jenkins Boulevard (former US Business Route 92).

US 92/SR 546 continues eastbound along Memorial Boulevard where it climbs a bridge over the CSX Vitis Subdivision and Florida State Road 539 with no access.

Across from the south side of Auburndale Cemetery the western terminus of Florida State Road 544 branches off to the southeast towards Legoland (formerly Cypress Gardens) and part of Haines City.

The routes become a one-way pair between Echo Street and Seminole Way, but before that pair ends, County Road 557 begins at Polemo Street, where it heads west for a block to CR 555, and then turns north towards Interstate 4; just past CR 557, US 17/92 turns east towards Haines City.

Along this stretch, the road intersects the Osceola Parkway in Kissimmee, SR 417 (Central Florida GreeneWay) at exit 11, and the Central Florida Parkway as it passes east of the resort area of Orlando that includes Walt Disney World and affiliated resorts, Sea World, and Universal Studios.

OBT then comes to a massive combined interchange with Florida's Turnpike and SR 528 (Beachline Expressway) in Sky Lake.

It crosses Lake Estelle on the Andrews Causeway before reaching the border between Orlando and Winter Park.

The routes leave the concurrency with SR 46 at the north end of County Road 15 (once a branch of State Road 15), and then runs north towards the interchange with Interstate 4 (SR 400) where US 17/92 turns west along the south shore of Lake Monroe (part of the St. Johns River).

North of Orange City is a trumpet interchange with State Road 472, a four-lane connection to Interstate 4.

US 92 passes through downtown DeLand on Woodland Boulevard, crossing State Road 44 at New York Avenue.

From DeLand to its terminus in Daytona Beach, US 92 carries the local name, International Speedway Boulevard, running through Tiger Bay State Forest then passing a connecting road towards Interstate 4 with a westbound only flyover off-ramp and an eastbound only on-ramp from exit 129.

The highway serves as the southern terminus of LPGA Boulevard then has an interchange with Interstate 95 before it passes by the Daytona International Speedway.

US 92 spans the Halifax River and Intracoastal Waterway via the Broadway Bridge before reaching its eastern terminus at SR A1A.

US 92 was signed along the following roads in 1927: When the bypass of downtown Tampa on SR 17 (Hillsborough Avenue) opened in the early 1930s, US 92 and US 41 were rerouted to use it.

In 1947, the route was extended east in Daytona Beach across the Intracoastal Waterway and the Halifax River after the Broadway Bridge was reconstructed and opened.

In late 2013, the Florida Department of Transportation began an $80 million project to construct a flyover interchange with US 17-92 traveling over SR 436 in Casselberry.

Sloan Avenue becomes a divided highway between the 12-foot-6-inch (3.81 m) bridge beneath the CSX Lakeland Subdivision, only to emerge at the intersection of West Main Street where it turns east.

The road makes a brief left turn onto Massachusetts Avenue in front of Lake Mirror for one block, then turns right at the end of Cedar Street where it runs along the north shore of Lake Mirror passing by Lakeland Amtrak Station.

From there it has an intersection with US 98 (SR 548), and after Lake Parker Avenue makes a north turn onto Tyler Road.