It was nominated for the first annual Manga Taishō award in 2008 and one of the Young Adult Library Services Association's 2008 Great Graphic Novels.

[1][2] Harutaro Hanazono, a cheerful and outspoken boy, enrolls at his new high school a month late, as he has been recovering from a bone marrow transplant to treat his leukemia.

[5][6] Comics Worth Reading's Johanna Draper Carlson criticises the first volume of the manga for its plot which "jumps around a good deal".

[16] Jason Thompson, writing for the appendix to Manga: The Complete Guide, describes Flower of Life as being Yoshinaga's "take on the high school comedy genre".

[19] Flower of Life was nominated by the Young Adult Library Services Association for inclusion on its list of 2008 Great Graphic Novels for Teens.