Much of the humor has a twist aimed at adults, in the style of shows by predecessor Soupy Sales (1950s-1970s), and later Pee-wee Herman (1980s).

The show featured character comedy, puppetry, some audience participation, musical guests, and Vivino's piano playing.

Local bands such as The Smithereens, The Shades, and R. Stevie Moore, along with such well-known performers as The Ramones, Tiny Tim, Benny Bell, Bon Jovi, Jan and Dean, Peter Tork, Squeeze, David Johansen, Blue Öyster Cult, Joe Jackson, and Cyndi Lauper also appeared on Vivino's program.

The show's first cast members in 1974 included Pat Cupo, Bob D. Caterino – known for his Groucho Marx skits, and Marc Nathan, the cameraman.

Later members were Scott Gordon, Craig "Mugsy" Calam, Richard "Netto" Cornetto, Jim Monaco, Art "Looney Skip" Rooney, Charlie Stoddard, David "Artie Delmar" Burd, and Clark the Wonder Dog.

The national syndication deal was seen as a huge step forward for the show, which up until that point could only be viewed in and around New Jersey and New York City on a single UHF channel and, at times, local cable.

Vivino has appeared on several television shows filmed in New York City including Law & Order, 100 Centre Street, and Cosby, and was a regular on the Sirius Satellite Radio program The Wiseguys Show on Raw Dog Comedy (channel 104) hosted by former The Sopranos cast member Vincent Pastore.

[citation needed] In 2000, Vivino played the bit part of an announcer in the Insane Clown Posse movie, Big Money Hustlas.

[5] From 1987 to 2013, Vivino broadcast on WVIP-FM 93.5 radio from New Rochelle, New York, where he played a wide range of Italian music on his Sunday afternoon program, The Italian-American Serenade.

In April 2013, Uncle Floyd's Garage Sale Music began on WVOX 1460 in New Rochelle, the sister station to his former radio outlet, WVIP.

This show features an eclectic variety of records from Vivino's large personal collection, most of which he found in thrift shops, yard sales and curbside garbage piles.

Beginning in June 2014, a second weekly Garage Sale Music program began airing and streaming on Sundays 9:00-Noon over WFDU 89.1 FM in Teaneck, New Jersey.

Vivino was selected to be the vocalist on Vince Giordano's 2020 recording of Ain't Misbehavin' but was replaced by Loudon Wainwright III due to a conflicting appearance commitment.

David Bowie, a fan of Vivino's television show, recorded the song "Slip Away" on his 2002 album, Heathen, as a tribute.

[9] The song "Work for Food" by Dramarama, on the 1994 album Hi-Fi Sci-Fi features the Uncle Floyd Show in the lyrics.