[1] Four "Flying G-Men" battle with enemy saboteurs intent on destroying American military defences.

[2]Three government aviators, Hal Andrews, Bart Davis and John Cummings called the "Flying G-Men", one of whom is disguised as "The Black Falcon", fight to protect the United States and its allies from an enemy spy ring and to avenge the death of the fourth Flying G-Man, Charles Bronson.

A plot to infiltrate all military factories and airports is discovered but the spy chief called "The Professor" is unknown.

[6] Film reviewer Jerry Blake in The Files of Jerry Blake described Flying G-Men serial as "... the least interesting of Columbia’s five in-house serial productions (the other four being 'Great Adventures of Wild Bill Hickok', 'The Spider's Web', 'Overland With Kit Carson', and 'Mandrake the Magician') ... its action scenes are uneven, its lead villains weak, and its plotting often disjointed.

However, it remains watchable and enjoyable throughout, thanks to an extremely likeable group of heroes and an unfailingly fast pace.