[5] In 1949, the Civil Aeronautics Board awarded Flying Tiger Line (along with Slick Airways) a scheduled cargo certificate for a transcontinental route from Los Angeles and San Francisco, California to Boston, Massachusetts.

The airline also played a major role in the construction of the Distant Early Warning Line, flying equipment to remote outposts in northern Canada and Alaska.

Flying Tiger Line adopted the Canadair CL-44 swing-tail aircraft in 1961, becoming one of the first carriers in the world to offer aerial pallet shipping service.

On 15 November that same year, a modified Flying Tigers Boeing 707-349C made the first ever aerial circumnavigation of the Earth via the poles, in 62 hours 27 minutes.

Aircraft loaders had earlier refused to work at the extreme 30 feet (9 m) height necessary for loading freight on the upper deck, so the "supernumerary area" or "hump" was configured with 19 first class seats instead which were used to transport livestock handlers, charter agents and mechanics as well as dead-heading pilots and flight attendants.

Two examples were thoroughbred racehorses and show animals from Stansted, England to the Melbourne Cup, as well as breeding stock cattle (milk supply) to nations such as Japan and Thailand.

Flying Tigers also made livestock carriers for airplanes, some comparable in external size and shape to the standard AMJ container used in the FedEx flight operations.

[11][12][2] The scheduled Boeing 747 passenger service route was New York City JFK Airport - Brussels - Tel Aviv operated several days a week.