Later, as part of the Treaty of La Pointe in 1842, the Fond du Lac Band and other Ojibwa tribes ceded large tracts of land located mainly in the Lake Superior watershed in Wisconsin and the western Upper Peninsula of Michigan.

Under this 1854 treaty, the US established the Fond du Lac Indian Reservation farther up the Saint Louis River, at its present location.

In treaty discussions the US representatives were recorded as promising the inclusion of the Perch and Big lakes, but these were excluded from the original reservation.

The FDL operates social services, tribal housing, a tribal police force, a natural resource building, a gas station, three community centers, and a private health clinic and pharmacy called Min No Aya Win Health Center.

The tribe also operates two satellite health clinics, one in Duluth, named The Center for American Indian Resources (CAIR), and another in Minneapolis, the Mashkiki Waakaaigan Pharmacy (Medicine House).

[1] As of the census of 2020, the total population living on Fond du Lac Reservation and Off-Reservation Trust Land was 4,184.