There, animal-rights activists led by Mark Hales (Réal Andrews) and Neil's girlfriend Alex Reed (Lisa Schrage) are protesting the work of Prof. Edmund Delhurst (Colin Fox), who claims to study cancer but in fact subjects animals to experimentation seeking a cure for baldness.

That night, the activists (minus Alex) break into the complex to trash Delhurst's lab and accidentally release the now-giant rats, which kill Mark and escape into the campus' utility tunnels.

Delhurst's assistant, a janitor named Zeke, is attacked, but the surviving exterminator, despite taking several bites to his arms and face, appears and burns the rat.

Although Lieutenant Weizel is convinced of the threat, Dean White remains skeptical and refuses to shut down the campus, due to the upcoming grand opening of the university's new sports complex.

Neil uses the enlarged but still-docile Louise, who is in heat, to lure the giant (male) rats into the university courtyard, where Weizel and his men gun them all down.

[citation needed] Paul Lê of Bloody Disgusting said of the film, "As positively junky and sleazy as Gnaw: Food of the Gods II is, it is also immensely fun.