[1][2][3][4][5] Wheeler began his acting career at the age of seven when he booked the role of a Cambodian boy in the film The Incredible Burt Wonderstone, opposite Steve Buscemi, who presented him with a rabbit as a pet that Wheeler's character took home to his family for dinner.

He plays the middle son of the Huang family alongside his television parents Randall Park and Constance Wu.

[6] Wheeler appeared on the Hallmark Channel's Home and Family on March 3, 2015, where he talked about Fresh off the Boat.

[9] In 2016, Wheeler collaborated with Fresh off the Boat costars Hudson Yang, Ian Chen, and ISAtv (founded by Wong Fu Productions) to produce a web series focusing on the interests of the Asian American Youth community in the hope of inspiring the youth from all over the world to go out and be active and curious.

[11] On December 19, 2017, Wheeler hosted Kore Asian Media's 16th annual "Unforgettable Gala's" Fresh Off the Carpet event where he interviewed award recipients and celebrities including Maggie Q and Ross Butler.