Fort Branch had its start in the year 1852 by the building of the railroad through that territory.

[5] On April 3, 1989, an F3 tornado passed through the town causing between 5 and 50 million dollars in damage.

[6] On February 28, 2017, an EF3 wedge tornado, originating in Crossville, Illinois, passed to the north of the town, destroying or heavily damaging several structures along Indiana 168.

[12] Like Princeton, Fort Branch is also largely a blue-collar town although of somewhat smaller size.

As the Emge plant was starting to close, Toyota announced that it would be building a manufacturing facility on a patch of farmland located halfway between Fort Branch and nearby Princeton.

While most of the suppliers for the new Toyota plant are located closer to Princeton, most of the population gains from employees moving closer to work moved into either Fort Branch, or into Haubstadt or Owensville.

Recently, Vincennes University announced plans to build an advanced manufacturing education facility just south of Fort Branch along U.S. 41 to provide such education to an area becoming more diverse in manufacturing methods.

This is expected to provide a major boost to lifestyle in the Fort Branch-Haubstadt Area.

By June 22, the fire had destroyed the vacant meat processing plant portion of the complex but was put out.

Sheriff Thomas Beloat, noted for his bravery in stopping a lynching in Gibson County, mentioned in an essay by Mark Twain, The United States of Lyncherdom.