Fort Defiance is a historic plantation house located near Lenoir, Caldwell County, North Carolina.

[2] This location on the Yadkin River was originally built upon by the troops serving under Elijah Isaacs in the summer of 1776.

[3] The house was listed on the National Register of Historic Places in 1970.

[1] Western North Carolina politician George Washington Hayes married his second wife at Fort Defiance on February 6, 1842.

This article about a property in Caldwell County, North Carolina on the National Register of Historic Places is a stub.