Fort Hill, also known as the John C. Calhoun House and Library, is a National Historic Landmark on the Clemson University campus in Pickens County, South Carolina, United States, near the City of Clemson.

[4] From 1825-1850, the house was the home of noted proponent of slavery and constitutional Nullification, John C. Calhoun, the 7th Vice President of the United States.

Clemson University was established on the Fort Hill slave-operated plantation site in 1889, and in accordance with the terms of its inheritance, has maintained the house and its immediate parcel as a museum and library — all that remains of what originally was an approximately 1,000 acre plantation estate.

In his 1888 will, Clemson bequeathed more than 814 acres (329 ha) of the Fort Hill estate to the State of South Carolina for an agricultural college with a stipulation that the dwelling house "shall never be torn down or altered; but shall be kept in repair with all articles of furniture and vesture...and shall always be open for inspection of visitors.

"[6] Clemson University has operated Fort Hill as a house museum as stipulated in the will.