Living and working at the fort, the Marines traded extensively with the local Creek Native Americans and cultivated friendly relations with them.

The French would trade European goods such as Flintlock guns, ammunition, and gunpowder, iron tools, knives, glass beads, copper pots, and wool blankets in exchange for local food stuffs, fur and deerskins.

According to tradition, the French commander Captain Jean Baptiste Louis DeCourtel Marchand married the high-status Creek woman Sehoy in about 1720.

Later generations of Sehoy's descendants include the Creek chiefs Alexander McGillivray, and William Weatherford, who inherited their status in the matrilineal tribe from their mothers' clans.

Due to the poor living conditions at the fort, which was neglected by the French government, the troops mutinied in 1722.

The imprisoned officers managed to escape, and with the help of nearby Creek, they captured the mutineers and sent them to Fort Conde in Mobile for punishment.

In 1776 the naturalist William Bartram noted visiting the area while studying local flora and fauna.

Archeological excavations have been continuing at the site, supervised by Dr. Craig Sheldon of Auburn University at Montgomery.

In the 1980s the park became a property of the Alabama Historical Commission and the incorrectly built fort was dismantled and recycled to partially construct a "correct" replica of Ft. Toulouse adjacent to the original site, allowing for a future reconstruction of Ft. Jackson on the actual site once occupied by both forts.