The Fort Wayne Railroad Bridge, listed as the Pennsylvania Railroad Bridge on the National Register of Historic Places, is a double-deck steel truss railroad bridge spanning the Allegheny River in Pittsburgh, Pennsylvania.

The upper deck carries the Fort Wayne Line with two tracks of Norfolk Southern and Amtrak traffic.

[citation needed] The 1868 bridge was a five-span wrought-iron lattice truss built for the Pittsburgh, Fort Wayne and Chicago Railway with two simple plate girder spans as approach roads at each end.

The lower level was used by local freight trains switching in the Downtown area and the Strip District.

Its tracks were removed in the 1980s as part of a major track and platform realignment through Pennsylvania Station.