The Fort Wayne and Jackson Railroad was a railway company in the United States.

That company consolidated two older companies, the Jackson, Fort Wayne and Cincinnati Railroad of Michigan and the Fort Wayne, Jackson and Saginaw Railroad of Indiana.

The final 41.8 miles (67.3 km) from Angola to Fort Wayne, Indiana, was finished on December 5, 1870.

[2] In 1976, several small sections within the vicinity of Fort Wayne, Jackson, and Waterloo were conveyed to Conrail.

[5][6] The new short-line railroad Hillsdale County Railway took over the section between Bankers and Pleasant Lake.