Under Roman Emperor Vespasian (69–79) or Titus (79-81), it was elevated to the rank of municipium, and under the Severan dynasty (193-235) to that of colonia (Cillilana).

[3] One noted monument is the Tomb of the Flavii, built for local landowner Titus Flavius Secundus in the late second century AD.

[4]" The theater was built at the end of the first century AD, probably to celebrate elevation of the town to a municipium,[5] It was restored, and reopened for performances in 2018.

During World War II, from January to March 1943, the Germans operated a forced labour camp for Jews in the city.

[12] Since its nominal restoration in 1925, the Latin titular bishopric has had the following incumbents, both of the lowest (episcopal) rank: Kasserine is located in western central Tunisia.