Four Corners Regional Airport was previously served by many commercial air service providers and was at one time was the second busiest in the state of New Mexico, behind the Albuquerque International Sunport.

Frontier Airlines (1950-1986) continued to serve Farmington with DC-3s through the 1950s and added flights to Phoenix making several en-route stops as well.

The Denver flights were then reverted to Convair 580 aircraft operated as Frontier Commuter before all service was discontinued in early 1985.

[5] Aspen Airways introduced British Aerospace BAe 146-100 jets between Farmington and Denver with a stop in Durango beginning in 1985 but ended all flights in March 1990 when the carrier was sold to Mesa Airlines.

Mesa Airlines, founded in Farmington, began in 1980 with service to Albuquerque using small Piper prop aircraft.

Flights to Denver began in April 1990 when Mesa became a United Express affiliate after purchasing certain assets and routes of Aspen Airways.

Mesa has since grown into a much larger air carrier and now operates an all regional jet fleet flying for several major airlines via respective code sharing agreements.

The service was set to begin on October 15, 2020, but was delayed by the COVID-19 pandemic and later cancelled due to a shortage of pilots at SkyWest.

For the period ending July 31, 2021, there were 87 aircraft based at this airport: 70 single-engine, 10 multi-engine, 1 jet, 4 helicopters, and 2 ultralights.

The data below lists annual total aircraft operations from the FAA's Air Traffic Activity System, 2009 through 2021.