[1] PSCH is affiliated with the Penn State College of Medicine and is located at the Milton S. Hershey Medical Center.

The hospital provides comprehensive pediatric specialties and subspecialties to infants, children, teens, and young adults aged 0–21[2][3] throughout central Pennsylvania and surrounding regions.

[6] Penn State Health Children's Hospital is the sole beneficiary of charity, Four Diamonds which started in 1972 to provide monetary support to childhood cancer patients at PSCH.

[11] In fall 2020 a vertical expansion on the building was completed adding three floors and moving the Women and Babies Center, a 56-bed Level IV neonatal intensive care unit (NICU) and the state's only Small Baby Unit from the former location in the main hospital.

[12][13][14] In July 2020, grocery store company, GIANT donated $1 million to the hospital to help support the three-floor expansion, expand the pediatric trauma and injury prevention program, and to expand the "Penn State PRO Wellness Healthy Champions program.