[12] To learn the trade, Laurie apprenticed with Nathan Stackhouse, who was based in South Jersey and had a master's degree in wine-making,[10] while Matty consulted wine growers in Sonoma County, California.

[10] Laurie eventually retired and became an Episcopal priest, while Matty continued to run the business with four full-time managers and ten part-time staff.

[10] The winery also hosts monthly events such as wine-tasting and barefoot grape-stomping,[11] and has participated in New Jersey wine festivals each year in September.

[7][15] It is the only winery in New Jersey that produces wine from Delaware, Léon Millot, and Marquette, which are red hybrid grapes known for their tolerance of cold weather.

[18][19] Four Sisters has a plenary winery license from the New Jersey Division of Alcoholic Beverage Control, which allows it to produce an unrestricted amount of wine, operate up to 15 off-premises sales rooms, and ship up to 12 cases per year to consumers in-state or out-of-state.