[3] After nearly 40 years at that location, in 1912, the congregation built a new building on Pine Street (now North Michigan Avenue), which was then a fairly undeveloped part of the city.

The congregation employed architect Ralph Adams Cram to create a Gothic Revival building of dressed limestone.

[4] The church building is the oldest structure on North Michigan Avenue, with the exception of the Chicago Water Tower, and is listed on the National Register of Historic Places.

M. Woolsey Stryker (1885–1892), a widely quoted pundit as well as prolific hymnwriter, served as pastor but left Chicago to become President of his alma mater, Hamilton College, in upstate New York.

In March 2014, Fourth Presbyterian's members voted at a congregational meeting for the Reverend Shannon Johnson Kershner to lead the church as its next pastor commencing on May 1, 2014.