A native of Annecy in the French Alps, she became known for her role as Dorothy Doll in the La Minute Blonde sequence from Le Grand Journal on Canal+.

After obtaining her baccalauréat, she moved to the region of Alsace where she studied modern literature at the Marc Bloch University of Strasbourg.

In 2007, she had supporting roles in comedy films Tel père telle fille and Ma vie n'est pas une comédie romantique.

The sequence was included in Le Grand Journal on Canal+ hosted by Michel Denisot during the first and second season from September 2004 to June 2006.

Frédérique Bel has also played in television films such as the 2006 mini-series Petits meurtres en famille, and later in the 2012 crime series Profilage, where she portrays a manipulating lawyer until the end of the third season.

She began the same year in the third season of Canadian science fiction animated series Tripping the Rift, where she voiced the main character Six in the French version.

From 2001 to 2004, Frédérique Bel appeared in several television advertisements for various brands like Bouygues of Étienne Chatiliez, Darty of Yvan Attal, EDF of Jean-Pierre Jeunet, and also Mir Laine of Philippe Lioret where she portrayed the fairy.

She later appeared in an advertisement for the optical brand Krys with other celebrities, including Alain Delon, Jane Birkin, Michel Blanc and Frédéric Beigbeder.

She posted on her Twitter account a picture of her naked to defend the right for the IVG (Interruption Volontaire de Grossesse, the French equivalent for abortion).

[6] In November 2014, her Facebook account was blocked for seven days for the head comment she posted on two articles she shared about trafficking of women in the Islamic State.

[7] She also added in an attached link the message she wrote them stating that she defends women's rights in the world and that she was angry for being blocked.