Kēichirō Kishi is an extremely talented pathologist with amazing clinical eye, helped by his vast amount of knowledge, but he is also known as an eccentric and arrogant troublemaker.

Written by Bin Kusamizu and illustrated by Saburō Megumi, Fragile started in Kodansha's seinen manga magazine Monthly Afternoon on June 25, 2014.

[3] The manga was adapted into a Japanese television drama starring Tomoya Nagase as Keiichirō Kishi and Emi Takei as Chihiro Miyazaki.

It was directed by Junichi Ishikawa, scripted by Atsuko Hashibe, planning by Hiroaki Narukawa and produced by Hiroshi Kobayashi.

[34][35] Alongside Sanju Mariko, Fragile won the 42nd Kodansha Manga Award in the general category in 2018.