Its south end is at Amtrak's Northeast Corridor, over which CSX has trackage rights to reach the Middleboro Subdivision at Attleboro and the Boston Subdivision in Boston (via the Fairmount Line).

Its north end is at the Framingham/Worcester Line; the Fitchburg Secondary continues northwest from Framingham.

[2] Special MBTA Commuter Rail trains use the line between Mansfield and Walpole for access to Foxboro station, which is used for New England Patriots home games and other major events at Gillette Stadium.

[3] Regular commuter service to Foxboro ran as a pilot in 2019-2020, and became permanent in 2022.

Effective June 17, 2015, the state purchased the line for $23 million with the intent to upgrade it for faster game day service and eventual full-time passenger service.