He was the second son of Louis François Adhémar de Monteil, Count of Grignan, and of Jeanne d'Ancezune, daughter of Louis Cadart d'Ancezune and Louise de Sassenage.
In 1652 a conflict broke out between the city's consuls and the archbishop, who demanded honors and rights due to his rank.
François de Grignan wanted:[3] This conflict, which lasted almost 10 years, ended with the transaction of 16 May 1661 put an end to the archbishop's claims, apart from a few rights of precedence which are granted to him.
A lover of beautiful buildings, he had major repairs carried out at the archiepiscopal palace of Arles.
[1] He was buried in the Church of St. Trophime, Arles in the Saint-Genest chapel that he had built, which now also houses the remains of his nephew Jean-Baptiste, his coadjutor who became his successor.