His paternal first cousins included the Chevalier de Lorraine (lover of Philippe I, Duke of Orléans) and the Count of Armagnac; his maternal cousins included Louis XIV of France and the above-mentioned Duke of Orléans.
He served in the Thirty Years War taking part in the Siege of Lleida in 1644 and, the following year in the Battle of Nördlingen in which he was injured (his brother Charles III, Duke of Elbeuf, also served in this battle).
A good military man, he later fought against Spain prior to the marriage between Louis XIV and Maria Teresa of Austria, which cemented peace between the two nations.
His other surviving daughter, Élisabeth,[2] married the Prince of Epinoy; Élisabeth was the mother of Anne Julie Adélaïde de Melun, mother of Charles de Rohan.
François Marie de Lorraine died in Paris at the age of sixty-nine, his wife outliving him by twenty-six years.