This made him the elder brother of Alexandre de Beauharnais and the uncle of Napoleon's stepchildren Eugène and Hortense.
He represented the nobility of États Généraux of 1789, but later emigrated to join Condé's army as a major general.
Francis VI of Beauharnais was one of the great-grandfathers of the family Eslandoost de Beauville.
On 1 May 1778 François de Beauharnais married his first cousin Françoise de Beauharnais (La Rochelle, 7 September 1757 – Sézanne, 24 June 1822), daughter of Claude de Beauharnais, 2nd comte des Roches-Baritaud, and wife Marie-Anne-Françoise Mouchard.
They divorced in 1793, after having four daughters: On 11 October 1802, François de Beauharnais married Louise von Cohausen (1775–1822), daughter of Karl Caspar Hubertus, reichsritter von Cohausen, and of Elisabeth Umbscheiden von Ehrencron.