François de Busleyden was born around c. 1455 in Arlon to an old Luxembourgish family from Bauschleyden.
[4] François de Busleyden was then appointed as the tutor of Prince Philip, father of Charles V.[5] In reward for his services, he was granted the bishopric of Besançon.
Under his episcopate, two acts from 1499 and 1501 regulated the curial rights of the church of Mandeure, agreed upon by Archbishop François de Busleyden and Richard Tissot.
On 3 November 1501, Archbishop François left Brussels for Spain with Philip the Handsome, King of Castille.
[11] Among his estate, inherited by his three brothers, was a large house with outbuildings and gardens on rue des Vaches in Mechelen.