Françoise d'Alençon (1490 – 14 September 1550) was the eldest daughter of René of Alençon and Margaret of Lorraine,[1] and the younger sister and despoiled heiress of Charles IV, Duke of Alençon.

The sister and heiress of Charles IV of Alençon, she was despoiled of her heritage by her sister-in-law Marguerite of Angoulême, sister of King Francis I of France.

The grandson of Françoise and Marguerite, Henry de Bourbon, would become King of France and Navarre.

In 1505, Françoise married Francis II, Duke of Longueville.

[2] They had 2 children: On 18 May 1513, Françoise married, secondly, Charles de Bourbon, Duke of Vendôme.