In 1546, she and her spouse were appointed governor and governess to the Dauphin, and subsequently became the main governor and governess to all the children of king Henry II of France and Catherine de Medici.
The royal children were raised under their direct supervision, under the orders of Diane de Poitiers.
[1] As head governor and governess, the d'Humières couple headed the staff of the royal nursery, staff of about 250 people, which included tutors and governesses of lower rank, who attended more directly to each of the children.
From 1548, the nursery was expanded to include Mary, Queen of Scots and her governess (Janet Stewart, Lady Fleming, later Françoise de Paroy) and personal Scottish entourage of about 30 people.
When her spouse died in 1550, he was succeeded as governor by Claude d'Urfé, who was given charge of the finances of the royal nursery, but the king confirmed Françoise d'Humières as main governess with the responsibility for his children.