She married Louis Phélypeaux, marquis de la Vrillière, on 1 September 1700, but he died only five years later in 1725, and she was left widowed.
She was appointed dame d'atour to queen Marie Leszczyńska on 25 August 1731, succeeding her mother.
She became the queen's personal friend and favorite among the ladies-in-waiting alongside Marie Brûlart, duchesse de Luynes.
She introduced her son, Louis Phélypeaux, comte de Saint-Florentin, at court, where he became state secretary.
She disliked the position of her granddaughter, Louise Julie de Mailly-Nesle, comtesse de Mailly, as royal mistress, and died in the middle of an intrigue to replace Louise Julie with her younger granddaughter, Marie Anne de Mailly-Nesle.