[2] Kuzui received her master's degree from New York University and was a script supervisor for a decade, prior to her first film, 1988's Tokyo Pop, which she co-wrote and directed.

The movie was shown at the 1988 Cannes Film Festival and received critical acclaim[citation needed] for its depiction of an American woman trying to make sense of the Japanese youth culture.

[7] In 1997, Kuzui began working with Trey Parker and Matt Stone and produced their film Orgazmo.

[citation needed] The Kuzuis worked with artist Keith Haring to establish Pop Shop Tokyo, an art project recognized by museums around the world.

[8][9] Kuzui is a contributing writer at the Nikkei Asian Review and Tokyo bureau chief for Culinary Backstreets.