His unusually intimate friendship with Anne Villiers, Countess of Morton (a cousin of his first wife, Anne Ayliffe), never seems to have posed a threat to the happiness of his second marriage, and in any case, this friendship ended in a bitter quarrel some time before Lady Morton's death in 1654.
Frances's death after a short illness was undoubtedly a great blow to her husband, at a time when he was fighting desperately to stave off the threat of impeachment.
In his will of 1666, he refers to Frances as "my dearly beloved wife who hath accompanied and assisted me in all my distress with greater resignation and courage and in all respects deserved much more from me than I can repay to her".
Another tribute to her character came from the diplomat Henry Coventry, who was then engaged in the peace negotiations at Breda, and wrote that the news of Frances's serious illness made him "very unfit for the business".
She appears as a character in The Piccadilly Plot, the seventh of the Thomas Chaloner mystery novels by Susanna Gregory.