Little is known of either Lady or Lord Bergavenny, except that the latter was accused of behaving in a riotous and unclean manner by some Puritan commentators.
Her father was a soldier and the eldest son of George Manners, 11th Baron de Ros and his wife, Anne St Leger.
By St Leger, Lady Frances was a great-granddaughter of Anne of York; the oldest sister of Edward IV and Richard III.
Lord and Lady Bergavenny had one daughter Mary Neville, Baroness Le Despenser (25 March 1554 – 28 June 1626).
Her Praiers in prose and verse were later published in 1582, in the Second Lamp of Thomas Bentley's anthology of Protestant women writer's prayers, The Monument of Matrones.
In a deathbed dedication of her work to her daughter, she calls it a "jewell of health for the soule, and a perfect path to paradise."