Her work is focused on a comparative exploration of coloniality, primarily in Puerto Rico and the United States, with special attention given to the intersections between race, ethnicity, gender, sexuality, and politics.
[1] She has also contributed to the Huffington Post, El Diario/La Prensa, and 80 Grados, and since 2008 has served as a Global Expert for the United Nations Rapid Response Media Mechanism.
In 1989, with Peter Biella she co-directed AIDS in the Barrio: Eso no me pasa a mí, an educational documentary about the situation of the Puerto Rican community in Philadelphia and their responses to the HIV/AIDS crisis.
The book also has chapters on West Side Story, Ricky Martin, and Holly Woodlawn, with interesting insights about Puerto Rican homosexuality in the United States.
Negrón-Muntaner has also edited several additional books, including None of the Above: Puerto Ricans in the Global Era (Palgrave 2007)[11] and Sovereign Acts (South End Press, 2009).
She is the founder of Miami Light Project's Filmmakers Workshop, the organizer/fundraiser of several conferences on Puerto Rican/Latino affairs, and a founding board member and former chair of NALIP, the National Association of Latino Independent Producers.