Along with his mentor, Junípero Serra, Palóu worked to build numerous missions throughout Alta and Baja California, many structures of which still stand today.
According to biographer/translator Herbert E. Bolton, "Fray Palóu was a diligent student, devout Christian, loyal disciple, tireless traveler, zealous missionary, firm defender of the faith, resourceful pioneer, successful mission builder, able administrator, and fair minded historian of California.
"[citation needed] Palóu is particularly noted for his pious biography of Serra, and for his multi-volume early history of Spanish Empire exploration and occupation of the Californias.
Coming from simple beginnings, Palóu was born in 1723 at Palma, on the Island of Majorca, and began religious work early in his life as he entered the Franciscan Order around the age of seventeen in 1739.
However, the biggest part of Palóu's journey would not begin until 1767, when he and fourteen other Franciscan friars were sent north to extend their efforts and replace many of the Jesuit missionaries who had been previously expelled from Spain.
When the Lower Californian missions were turned over to the Dominican missionaries, Palóu was able to rejoin his brethren and mentor in Upper California.
Palóu greatly assisted in the placement of friars and recorded historical data, the only surviving account of some aspects of the early California missions.
In 1774, Palóu accompanied Captain Rivera's expedition to the Bay of San Francisco, and on December 4 planted the cross on a hill he named "Lobos" (wolves), which sits in clear view of the Golden Gate and Pacific Ocean.
[1] Palou returned to Lobos in 1776 with the De Anza expedition and, on June 28, offered up the first mass at the future site of Mission Dolores, which Palóu founded but a few weeks later.