[3] She is the daughter of a Russian-American father, the bureau chief of Time , and an Italian mother, a fashion publicist for Valentino and Giorgio Armani.
[8] At the Royal College of Art,[8] Amfitheatrof met and worked with Giovanni Corvaja, who taught and mentored her to create unique alloys, like blue or elastic gold.
[4] After the Royal College of Art, she went to Padua, in northern Italy, to become an apprentice for Paulo Maurizi, who had previously worked with Corvaja.
[9] After her studies, she came back to London and launched her collection with a show presented by Jay Jopling of White Cube Gallery.
[12] In 2001 she set up RS&A, a London-based contemporary artist agency with Mark Sanders and Julia Royse.
[4] In 2010, Amfitheatrof organized and curated the Damien Hirst exhibition "Cornucopia" at the Musée Océanographique in Monaco.
[14] The following year, Amfitheatrof curated and selected 23 works from the Francois Pinault Collection of Contemporary Art exhibited for the first time in Asia in a show entitled Agony and Ecstasy.
[16] In 2010, Amfitheatrof opened the Gucci Museo in Florence as Head Curator, featuring the video art titled "Amore e Morte" (2011) of American artist Bill Viola; followed by British artist Paul Fryer[17]'s "Lo Spirito Vola" (2012); then Cindy Sherman's "Early Works" (2013) exhibition, that included the photographic series "Bus Riders" and "Murder Mystery", and a short film "Dollhouse".
[18] The last show Amfitheatrof curated was the 2013 solo exhibition of Portuguese artist Joana Vasconcelos: Red Independent Heart (2010), Psycho (2010), Lavoisier (2011), and Hand Made (2008).
She designed a range of minimalist necklaces, cuffs, and rings meant for layering and daily wear, and also created the advertising campaign, which was shot by Craig McDean, styled by Karl Templer and featured Freja Beha Erichsen.
During her three and a half years as the head design director, she approved the repositioning of the Haute Joaillerie for the Tiffany Blue Book Collection, that comprised 250 unique pieces.
[27] In the 89th Academy Awards, both Emma Stone and Jessica Biel wore Amfitheatrof's "Whispers of the Rainforest" jewelry.
Amfitheatrof is also responsible for the design of the East-West Automatic watch collection, featuring a dial turned 90 degrees.
[33] In March 2019, Amfitheatrof launched her line originally under the name Thief & Heist and then rebranded in 2022 to Pauer, a new drop-driven, direct-to-consumer collection.
[40] In July 2022 the Louis Vuitton Spirit High Jewelry Collection was launched, inspired by mythological creatures.