Francesca Lebrun (née Franziska Dorothea Danzi; 24 March 1756 – 14 May 1791) was a celebrated German soprano associated with the court at Mannheim, as well as an accomplished composer of sonatas.

As a singer, she was renowned for her vocal dexterity and was highly sought after by such notable composers as Anton Schweitzer, Ignaz Holzbauer, and Antonio Salieri to sing the lead roles in their most challenging operas.

There seems to be some debate whether she first performed in Gassmann's L'amore artigiano in May 1772, or Sacchini's La contadina in corte, the role for which she earned the title of court musician (virtuosa da camera).

At the opening of the Teatro Alla Scala in Milan on 3 August 1778, Francesca Lebrun was the female lead in Antonio Salieri's opera Europa riconosciuta.

A celebrated coloratura soprano, she sang on major operatic and concert stages through Europe, including England, Germany and Italy, to great acclaim.