Robert De Niro is her godfather and when she was growing up, she called Leonardo DiCaprio "Uncle Leo".

[2] "My dad was editing the The Wolf of Wall Street while I was doing homework on the staircase and all I could hear was sex scenes," she told Nylon.

Francesca attended film-related summer programs at Atlantic Theater Company Acting School and New York Film Academy.

[3][2] When director Luca Guadagnino cast her without knowing her last name, "it was one of the first times I was proud of myself," she told Nylon.

[5][3] In 2023, she worked with her father Martin Scorsese on a Bleu de Chanel commercial starring Timothée Chalamet.

[1] In July 2023, she gained popularity on TikTok after posting a 22-second video of her father with the caption "He's a certified silly goose.

[3] On February 5, 2024, Squarespace announced that Francesca and her father would appear in a commercial in the upcoming Super Bowl LVIII.