Francesco Barberini, iuniore (12 November 1662 – 17 August 1738) was an Italian Cardinal of the family of Pope Urban VIII (1623–1644) and of the Princes of Palestrina.

When his sister-in-law, Felice Ventimiglia Pignatelli d'Aragona separated from Urbano, she sought refuge with Francesco and joined a convent within his bishopric.

He was created cardinal by Pope Alexander VIII on 13 November 1690 with the dispensation of having an uncle (Carlo Barberini) in the Sacred College and for not having yet received the minor orders.

On 3 Mar 1721, he was named Cardinal-Bishop of Palestrina and on 16 Mar 1721, he was consecrated bishop by Fabrizio Paolucci, Cardinal-Bishop of Albano, with Vincenzo Petra, Titular Archbishop of Damascus, and Bernardo Maria Conti, Bishop Emeritus of Terracina, Priverno e Sezze, serving as co-consecrators.

In 1704 he commissioned Bernardino Cametti to create funerary monuments for his grandfather Taddeo and great-uncle Antonio Barberini in the family Church of Santa Rosalia in Palestrina.