He rose to fame as a singer during the summer of 2003, when he released his debut single, "La canzone del capitano", which became a hit in Italy.

Starting from 2008, Facchinetti presented the first four series of X Factor, the Italian version of the talent show created by Simon Cowell in the United Kingdom.

[8] Facchinetti's third single, "Ti adoro", a rap version of Luciano Pavarotti's song with the same title, was released in February 2004.

[9] In March of the same year, DJ Francesco competed in the 54th Sanremo Music Festival with the song "Era bellissimo", placing 11th in a field of 22.

[12] In March 2005, he competed for the second time in the Sanremo Music Festival, performing the song "Francesca" as part of the DJ Francesco Band.

[13] The song became the lead single from DJ Francesco's second studio album, Il mondo di Francesca.

[20] In September of the same year, he started to co-present the fifth series of L'isola dei famosi, from the Cayos Cochinos islands, in Honduras.

In the meanwhile, Facchinetti also presented the music show Scalo 76, the Italian Nickelodeon Kids' Choice Awards 2008, and Il più grande (italiano di tutti i tempi).

In 2014, Facchinetti returned to music, performing the song "Conta" for the Italian drama television series Braccialetti rossi.

[30] He also recorded the theme song for the second series of the same show, "L'inizio del mondo", a duet with Niccolò Agliardi, released as a single in 2015.

[32] During the reality show L'isola dei famosi, Facchinetti started an on-again off-again relationship with fellow contestant and Venezuelan television personality Aída Yéspica.