He was a member of the noble House of Loredan, head of its Santo Stefano branch, and the only Doge, as well as the last male, to be awarded the Golden Rose by the Papacy.

In the meantime, he was also the superintendent of the Chambers, of the Duties, of the Mint, of the Pumps, of the Feuds, cashier of the College, wise man of the Merchants, attorney of the Gold and Coins, deputy of the provision of funds, all secondary and not top positions.

In 1748 he refused the position of commissioner at the borders of the province of Friuli and Istria and returned to Venice where he resumed taking on ceremonial and medium-prestige roles and became close to the conservative faction within the Great Council.

[1] In July 1750, as a wise man of the Council, he was the main spokesman for Pope Benedict XIV's initiative to send an apostolic vicar to the Patriarchate of Aquileia.

[3] The surviving list of the individual items, however, allows us to estimate the cost at just over 38,600 ducats (of these, 2310 for the orchestra, 7635 for refreshments, 5800 donated to the people and 2140 to the arsenalotti).

[3] Despite this, one of the sonnets composed for the occasion complained of insufficient results, mocking the music and claiming that the "machine" of fireworks had funerary references.

[1] He did not have a particular interest in culture and had a limited library showing only a certain activism in the artistic field; in addition to being portrayed by minor painters such as Bartolomeo Nazzari and Fortunato Pasquetti, he designed the reconstruction of the commercial maps of territories and countries in the Sala dello Scudo in the ducal palace and the portraits of the last forty-six doges in the Sala dello Scrutinio.

There were also many buildings, agricultural lands and fields in the Venetian hinterland (Marghera, Meolo), in the Polesine (Canda, Anguillara Veneta, S. Martino di Venezze, Rovigo, Badia Polesine, Polesella) and in the Paduan area (Montagnana, Cittadella, Piove di Sacco, Altichiero), Trevigiano (Monastier, Conegliano, Asolo), Vicentino (Noventa Vicentina) and Verona, Friuli (Latisana) and Istria (Rovigno and Barban).

The conservative pressure groups were able to block these plans and imprisoned or exiled the reformist leaders, such as Angelo Querini, an important figure of the Venetian Enlightenment.

[1] By impeding the development of the reformist ideas, he possibly caused the small economic boom which started around 1756 with the outbreak of the Seven Years' War.The famed author and adventurer Giacomo Casanova was locked in the notorious lead chambers under Francesco Loredan's government in 1755 for suspicious activities, from which he managed his spectacular escape.