Francesco I Manfredi (died May 29, 1343) was the lord of Faenza from 1313 until his death.
He was the son of Alberghetto (or Alberghettino) Manfredi, one of the main Guelph leader of Romagna, from whom he inherited the lordships of Brisighella, Quarneto, and Baccagnano, to which Francesco added other lands starting from 1309.
He was capitano del popolo of Faenza from 4 January 1313 and of Imola from 9 November 1314.
He was able to regain briefly Faenza in 1340–1341, maintaining subsequently the title of patrician of the city.
He left nine children, including the future seigniors of Faenza Alberghetto, Malatesta, and Riccardo.