These religious brotherhoods had appeared at various times since the 14th Century in and around the city of Milan and were quite plentiful, but the only one to attain more than simply local importance was the ‘Fratres Sancti Ambrosii ad Nemus’ sometimes known as 'The Brethren of the Grove'.
During his life he is credited with performing several exorcisms including to members of several ducal and princely families, notably the bewitched Cardinal Charles of Lorraine and his relative, Eric, Bishop of Verdun.
Guazzo first diagnosed possession, but after five months of unsuccessful attempts at spiritual healing and in the summer of 1604, the diagnosis was changed to bewitchment as the cause of the poor Duke’s mental illness.
It was these direct experiences that inspired Guazzo to write his Compendium Maleficarum which was published in 1608 and was widely regarded among his contemporaries as the authoritative manuscript on Witchcraft.
In this work, Guazzo was greatly influenced by Duke Charles III of Lorraine’s leading lawyer and demonologist, Nicholas Remy (Remy produced one of the most important early works on demonology and witchcraft in 1595, Daemonolatreiae libri tres, and claimed to have sentenced to death over 900 people during witch trials between 1582–1592).