[3] His brother Giuseppe Pannini (Rome, 1720–1812) was an architect and archaeologist[2][4] who in 1762 completed the construction of the Trevi Fountain.
He then worked with Giovanni Volpato, a highly talented engraver from the Republic of Venice, who published, between 1772 and 1776, a large series of plates after the frescoes of the Raphael Rooms and the loggias at the Vatican, which gained him a considerable reputation.
Some of these plates[8] were subsequently hand-coloured by Francesco Panini and, while they did not necessarily reproduce the actual design or subjects of the loggias' vaults and pilasters, they became much in demand among visitors to Rome.
With the collaboration of Francesco Panini and Lodovico Teseo, Volpato published, between 1775 and 1777, a series of prints after frescoes painted by Annibale Carracci in the Galleria di Palazzo Farnese.
[9] Volpato also made an impressive panorama of Rome based on Francesco Panini's drawings, part of the Rijksmuseum collection.