The son of the assassinated Giacomo II da Carrara, he succeeded him as lord of Padua by popular acclamation.
In 1360 he obtained by Louis I of Hungary the cities of Feltre and Belluno with their territories, as well as Valsugana, which controlled the trades to Trentino.
In 1375-1381 he sided with the Genoa in the War of Chioggia, after which he obtained by Leopold III of Austria the city of Treviso.
The following year, however, Venice and Milan formed a coalition against Francesco, who was forced to abdicate in favour of his son and to go into exile in Lombardy.
Later Gian Galeazzo Visconti transferred him first to Como, and then to the Forni jail of Monza, where he died in 1393.