Francesco de' Medici (16 October 1614 – 25 July 1634) was the fourth son of Grand Duke Cosimo II of Tuscany and his wife, Maria Maddalena of Austria.

Prince Francesco was born at the Palazzo Pitti in Florence, the capital of his father's grand duchy.

[2] Along with his mother and Mattias, he visited Austria in 1631 in order to meet his uncle the Emperor Ferdinand II.

He fought in the Battle of Lützen during the Thirty Years' War but fled the scene.

His elder brother, Grand Duke Ferdinando, reprimanded him for his conduct in a letter dated 14 July.