He played for the Chicago Cubs, Montreal Expos, and Detroit Tigers of Major League Baseball.

Beltran spent three seasons (1997–1999) with the Arizona team, with a combined record of 1–3, with an earned run average (ERA) of 3.99 in 35 appearances.

On June 27, the Cubs called up Beltran to replace Jason Bere, who had gone on the disabled list with a contusion to his right knee.

[2] Beltran made his major league debut on June 28, 2002, in an interleague game against the crosstown rival Chicago White Sox.

The next day, the Cubs sent him back to West Tenn to make room for reliever Tom Gordon.

The Cubs briefly recalled him in June after David Kelton was sent down, but optioned him back to Iowa before he made an appearance.

He struck out 40 batters in 35 innings, but also gave up eight home runs, including a record-breaking 503-foot shot by Richie Sexson in Bank One Ballpark on April 26, 2004.

A week later, he was traded to the Montreal Expos as part of a four-team deal which sent Nomar Garciaparra to the Cubs.

[14] He missed much of the 2006 season as well, making a combined 10 appearances with the Gulf Coast Nationals and New Orleans Zephyrs, and was released at the end of the year.