Francis Clerke (c. 1665–1691) was an English politician who sat in the House of Commons from 1690 to 1691.
Clerke was the son of Sir Francis Clerke of Ulcombe and Rochester and his second wife Elizabeth Hastings, widow of John Hastings of Woodlands Dorset and daughter of John Cage of Brightwell Court Buckinghamshire.
He was educated at Magdalen College, Oxford, and entered Middle Temple in 1683.
However he interrupted his studies to volunteer against the Duke of Monmouth as a cornet of horse.
After the death of his father in 1686 and his half brother John in 1687, he inherited Ulcome and was able to maintain the family political interest in Rochester.